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* Toplam Okuyucu : 161, * Yayın Tarihi : 01-02-2008 - 11:11 (154 gün önce), * Ortalama Günde 1.04 okuyucu. * Karakter Sayısı : 2145 , Kelime Sayısı : 331 , Boyut : 2.09 Kb.

Preoperative fibrinogen levels as a predictor of postoperative bleeding after open heart surgery.

Ucar HI, Oc M, Tok M, Dogan OF, Oc B, Aydin A, Farsak B, Guvener M, Yorgancioglu AG, Dogan R, Demircin M, Pasaoglu I.

Department of Cardiovascular Surgery, Hacettepe University, Faculty of Medicine, Ankara, Turkey. hiu@hacettepe.edu.tr

BACKGROUND: Open heart surgery still involving major bleeding continues to be a major challenge after cardiac surgery and is also a significant cause of morbidity and mortality. Most hemostatic factors are intercorrelated with postoperative bleeding, and fibrinogen seems the most fundamental hemostatic risk factor for open heart surgery. METHODS: The study included 97 patients who underwent elective coronary artery surgery (78 men and 19 women; mean age, 60.9 +/- 10.3). Preoperative blood samples were obtained and preoprative quantitative determination of plasma fibrinogen levels were measured by the clotting method of Clauss using the fibrinogen kit. Patients were operated on by the same team and the same technique. The total amount of drainage blood from chest tubes was recorded after termination of operation. RESULTS: There were statistical significance between the fibrinogen levels and the drainage (r = -0.897, P < .001). Chest drainage was a mean of 972 mL (range, 240-2445 mL) in the first 48 hours after sternotomy closure. Fibrinogen level and relation to age was statistically significant (P = .015). There was no statistical significance between fibrinogen levels and gender (male gender = 400.7 +/- 123.0 versus female gender = 395.6 +/- 148.1; P = .877) and between drainage and gender (male gender = 968.2 +/- 538.5 versus female gender = 990.0 +/- 554.7; P = .876). Two patients (2%) died early after the surgery. There were no significant differences between the postoperative bleeding and cardiopulmonary bypass time (P = .648) or cross-clamp time (P = .974). CONCLUSION: The results of this study suggested that low preoperative fibrinogen level appears to be a useful diagnostic marker to assess the activity of the coagulation system, and that its preoperative level may serve as a potential risk factor for postoperative bleeding after coronary artery bypass surgery.

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Bu makaleden alıntı yapmak için alıntı yapılan yazıya aşağıdaki ibare eklenmelidir : "Preoperative fibrinogen levels as a predictor of postoperative bleeding after open heart surgery." başlıklı makalenin tüm hakları yazarı Doç.Dr.Ömer Faruk DOGAN'e aittir ve makale, yazarı tarafından TavsiyeEdiyorum.com (http://www.tavsiyeediyorum.com) kütüphanesinde yayınlanmıştır. Bu ibare eklenmek şartıyla, makaleden Fikir ve Sanat Eserleri Kanununa uygun kısa alıntılar yapılabilir, ancak yazarının izni olmaksızın makalenin tamamı başka bir mecraya kopyalanamaz veya başka yerde yayınlanamaz.

Doç.Dr.Ömer Faruk DOGAN Tarafından Yazılan Diğer Makaleler: Effect Of Cardiopulmonary Bypass On Plasma Levels Of Lipoprotein (A) İn Hypercholesterolemic Patients A New Technical Approach For Sternal Closure With Suture Anchors (Dogan Technique). Surgical Management Of İnfants With Congenital Lobar Emphysema And Concomitant Congenital Heart Disease. Assessment Of The Radial Artery And Hand Circulation By Computed Tomography Angiography: A Pilot Study. The Use Of Suture Anchors For Sternal Nonunion As A New Technical Approach (Demircin-Dogan Technique). Comparison Of The Pretreatment Effects Of Mixed Vasodilators (3-D Solution) On Radial And İnternal Thoracic Arteries By Using A 3-Dimensional Anaglyph Electron Microscope Technique. The Changes And Effects Of The Plasma Levels Of Tumor Necrosis Factor After Coronary Artery Bypass Surgery With Cardiopulmonary Bypass. Peripheral Gangrene Associated With Kawasaki Disease And Successful Management Using Prostacycline Analogue: A Case Report. Demonstration Of Coronary Arteries And Major Cardiac Vascular Structures İn Congenital Heart Disease By Cardiac Multidetector Computed Tomography Angiography. Predictive Significance Of Plasma Levels Of İnterleukin-6 And High-Sensitivity C-Reactive Protein İn Atrial Fibrillation After Coronary Artery Bypass Surgery.