Serum Magnesium Concentrations İn Type 1 Diabetic Patients:
MAKALE #1759 © Yazan Prof.Dr.Mehmet Emre ATABEK | Yayın Ekim 2008 | 3,631 Okuyucu
Serum magnesium concentrations in type 1 diabetic patients:
Relation to early atherosclerosis
Mehmet Emre Atabek
a,*, Selim Kurtoglu b, Ozgur Pirgon a, Murat Baykara c
a
Department of Pediatrics, Division of Pediatric Endocrinology and Diabetes, Selcuk University, Faculty of Medicine,
Cocuk Sagligi ve Hastaliklari, 42080 Konya, Turkey
b
Department of Pediatrics, Division of Pediatric Endocrinology and Diabetes,
Faculty of Medicine, Erciyes University, Kayseri, Turkey
c
Department of Radiology, Faculty of Medicine, Erciyes University, Kayseri, Turkey
Received 11 March 2005; received in revised form 13 May 2005; accepted 6 September 2005
Available online 7 October 2005
Abstract
Hypomagnesemia and sub-clinical atherosclerosis are common in type 1 diabetic patients, and are especially common in poorly
controlled and chronically treated diabetics. The aim of this study was to evaluate the relationships between serum magnesium (Mg)
and intima-media thickness (IMT), and functions of common carotid artery (CCA), accepted as markers of early carotid
atherosclerosis in type 1 diabetic patients. Serum magnesium levels were measured in 51 diabetic patients (26 girls and 25
boys). Age, duration of diabetes as well as major cardiovascular risk factors, including anthropometric and metabolic parameters
were matched between girls and boys. CCA structure and functions were measured by ultrasonography as IMT, cross-sectional
compliance (CSC), cross-sectional distensibility (CSD), diastolic wall stress (DWS), and incremental elastic modulus (IEM). The
difference for serum Mg was significant between diabetic girls and boys (0.75
0.09 mmol/l versus 0.86 0.14 mmol/l; p = 0.02).
Mg levels were correlated with IMT (
r = 0.58, p = 0.004) and DWS (r = 0.49, p = 0.01) in girls and with IMT (r = 0.55,
p
= 0.007) and DWS (r = 0.46, p = 0.03) in boys. In a multivariate regression model, Mg, systolic blood pressure and waist-hip
ratio emerged as independent correlates for mean IMT in girls with the total variance explained being 63%, and Mg and
triglycerides emerged as independent correlates for mean IMT in boys with the total variance explained being 68%. Mg did not
emerge as independent correlates for mean DWS in both girls and boys. Serum magnesium levels in children and adolescent patients
with type 1 diabetes are associated with early atherosclerosis.
#
2005 Elsevier Ireland Ltd. All rights reserved.
Keywords:
Type 1 diabetes; Atherosclerosis; Magnesium
1. Introduction
Cardiovascular disease is a common cause of morbidity
and mortality in type 1 diabetes
[1], and carotid artery
stiffness and intima-media thickness (IMT) measured by
ultrasonography are correlated with atherosclerosis and
cardiovascular disease in patients with type 1 diabetes
[2].
In comparison to the general population, cardiovascular
mortality is increased approximately four-fold and is
further magnified in diabetic patients with albuminuria
[1,3]
. In type 1 diabetes, the presence of traditional
cardiovascular risk factors may not entirely explain this
excess cardiovascular risk.
A magnesium deficiency has been described in
patients with type 1 diabetes
[4–6]. Such Mg deficits
www.elsevier.com/locate/diabres
Diabetes Research and Clinical Practice 72 (2006) 42–47
* Corresponding author. Tel.: +90 332 223 6350;
fax: +90 332 223 6181.
E-mail address:
meatabek@hotmail.com (M.E. Atabek).
0168-8227/$ – see front matter
# 2005 Elsevier Ireland Ltd. All rights reserved.
doi:10.1016/j.diabres.2005.09.002
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